My students and I work on interdisciplinary projects ... computer science, biology, and chemistry. A long-term project: predicting structural properties of disease causing protein mutants. More recently begun: machine learning, evolutionary genetics, as well as big data.
Our most recent work includes cMutant, a web server for an exhaustive screen enabling exploring the effects of amino acid substitutions via rigidity mutation maps, as well as drug resistance in silico screen methods.
Previously, I co-developed KINARI (with Naomi Fox, advised by Ileana Streinu), a suite of graph-based algorithms extending pioneering work of Jacobs and Thorpe, and tools, for studying the flexibility of biomolecules. I designed, developed, and deployed KINARI-Mutagen, the first rigidity-based approach for inferring the effects of mutations.
Word Clouds for my most recent (pacman) and last 10 (rook) publications are shown right. My 800m PR is 1:50.17 (FAT).