PDZ domains bind the extreme C-terminus of target proteins and are critical components of signaling and trafficking pathways. MotifAnalyzer-PDZ identifies enrichment trends for specific amino acids in a PDZ-binding motif-satisfying sequence across multiple organisms.
MotifAnalyzer-PDZ has been developed for, and tested on, Linux and Windows.
Requirements :
Downloadable source code :
MotifAnalyzerPDZ.py is a command-line program that processes and compares C-terminal decameric sequences of one or more FASTA files. See the README.md file in the github repo for full details, and release notes.
Example 1, Linuxpython3 MotifAnalyzer-PDZ.py -organisms organisms.txt -positions 1,3 -numResidues 6 -motifs P0:I P2:STExample 2, Windows
runInParallel.py -organisms all_organisms.txt -numResidues 6 -motifs P0:WIYAFLVM P2:ST -positions 1,3,5